Virocin 30 – 30 Day Supply
Virocin™ is a natural zinc ionophore. This patent-pending formulation enhances the absorption and bioavailability of the natural ionophore, thereby increasing the intracellular zinc levels.
What Makes Virocin™ Unique
Historically the problem with natural ionophores has been the very high dose required to compensate for their poor absorption and low bio-availability. Our patent pending formulation enables quercetin to be used as an effective zinc ionophore, at much lower concentrations then previously achievable. Based on animal studies, the effective dose of quercetin is known to be approx 5-6g per dose. This high dose is to overcome the low bio-availability. Virocin is able to act as a natural ionophore and increase intracellular zinc at just 1g per dose.
This patent-pending formulation enhances the absorption and bioavailability of the natural ionophore, thereby increasing the intracellular zinc levels.
Each Dosage (two capsules) will contain:
- 1000 IU Vit D
- 10mg Zinc (as zinc gluconate)
- 1000mg Quercetin (a zinc ionophore)
- 100mg Vit C (promotes bioactivity of quercetin)
- 100mg Ginger Root extract (gingerol)
- 40mg 6,7-Dihydroxybergamottin
- 10mg Piperine
Zinc as an Anti-viral
RNA dependent RNA Polymerase (RdRp) is an essential or core enzyme of the viral replication and transcription complex (called Viral RTC), which occurs within the cytoplasm of an infected cell. The intracellular level of zinc is however tightly controlled, since increasing the intake of oral zinc from diet sources will not impact intracellular zinc concentration. Zinc requires the assistance of a carrier molecule (known as an ionophore) to move it across the cellular membrane to achieve an intracellular concentration high enough to inhibit viral RdRp from hijacking the cells protein replication and transcription processes.
Virocin™ is not a zinc supplement, instead, it works to transport the body’s natural zinc reserves across the cell membrane. In those individuals, however, who are zinc deficient, an ionophore will be ineffective.
Virocin™ provides 10mg zinc per dose to compensate for those wanting to take VirocinTM but who might also have a zinc deficiency or dietary insufficiency.
te Velthuis AJW, van den Worm SHE, Sims AC, Baric RS, Snijder EJ, et al. (2010) Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. PLoS Pathog 6(11): e1001176. doi:10.1371/ journal.ppat.1001176.
Vitamin D and Respiratory Infections
In 2017, a global collaborative study confirmed that vitamin D supplementation can help protect against acute respiratory infections. The Harvard Gazette reported that the study was a participant-data meta-analysis of 25 randomized controlled trials and included more than 11,000 participants. It was published in the British Medical Journal. Several observational studies have associated low vitamin D levels with greater susceptibility to acute respiratory infections. “Our analysis has also found that Vit D helps the body fight an acute respiratory infection, which is responsible for millions of deaths globally, each year.”
The investigators found that a daily or weekly supplementation had the greatest benefit for individuals with the most significant vitamin D deficiency (blood levels below 10 mg/dl) — cutting their risk of respiratory infection in half — and that all participants experienced some beneficial effects from regular vitamin D supplementation.
In 2018, a review paper examined the effects of Vitamin D on the immune system, researchers suggested that vitamin D can modulate the innate and acquired immune system through the Vitamin D Receptor. This has prompted the further investigation that vitamin D should be used in fighting off difficult -to -treat viral infections, such as influenza.
Vitamin D Reference:
Adrian R Martineau, et al, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data BMJ 2017;356:i6583
Beata M. Gruber-Bzura Vitamin D and Influenza— Prevention or Therapy? Int J Mol Sci. 2018 Aug; 19(8): 2419.
QUERCETIN AS A ZINC IONOPHORE
In 2014, researchers from universities in Spain and Argentina, using an animal model, demonstrated that quercetin acted as zinc ionophore by transporting zinc cations through the plasma membrane and rapidly increasing the intracellular zinc levels. Researchers concluded that natural flavonoids such as quercetin can be used to modulate zinc homeostasis and regulate zinc-dependent biological pathways.
In 2014, researchers from the University of Michigan reported the following… “Quercetin has been shown to reduce viral internalization and replication in vitro, and viral load, lung inflammation and airways hyperresponsiveness in vivo.”
The probable mode of action for quercetin’s demonstrated anti-viral effect is through its action as a zinc ionophore and its ability to facilitate the inhibition of the viral replication and transcription complex by elevating intracellular zinc concentrations.
Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015;8(1):6. Published 2015 Dec 25. doi:10.3390/v8010006
Kinker B, Comstock AT, Sajjan US (2014) Quercetin: A Promising Treatment for the Common Cold. J Anc Dis Prev Rem 2: 111. doi: 10.4172/2329-8731.1000111
Overcoming the problem with Quercitin
Historically the problem with natural ionophores such as quercetin has been the very high dose required to compensate for the poor absorption and low bio-availability. Animal studies indicate that the amount of 5g per dose of quercetin would be required to achieve a zinc ionophore effect within the human body.
The patent-pending formulation developed for Virocin™ facilitates quercetin, as an effective natural zinc ionophore, at much lower concentrations than had been previously achievable.